La herencia autosómica dominante significa que un animal puede ser libre/normal (homocigoto normal), afectado (homocigoto anormal) o portador (heterocigoto). Carriers and affected will both have the symptoms of the mutation.
Explicación para veterinarios:
• Un animal es LIBRE/NORMAL y tiene dos alelos sanos (homocigoto normal). The animal will not acquire any symptoms.
• An animal is a CARRIER and has one healthy allele and one defective allele (heterozygote). El animal desarrollará los síntomas de la enfermedad.
• An animal is AFFECTED and therefore has two defective alleles (abnormal homozygote). El animal desarrollará los síntomas de la enfermedad.
Explanation for breeders:
• An animal is CLEAR/NORMAL, and in that case will have two healthy alleles (normal homozygote). This animal will not acquire any abnormalities when breeding and cannot pass on the abnormality to the next generation.
• An animal is a CARRIER, where it will have a healthy allele and a defective allele (heterozygote). El animal pasará el alelo mutante a la mitad de su descendencia. Carriers can themselves also become sick.
• An animal is a AFFECTED, which means it has two defective alleles (abnormal homozygote). Los animales afectados transmiten el alelo defectuoso a toda su descendencia en la próxima generación y también desarrollarán síntomas asociados con la enfermedad.
| Inheritance autosomal dominant: | Padres: | Reproductive cells: | Offspring: | Interpretation breeding: | Interpretatie veterinatian: |
|---|---|---|---|---|---|
| NORMAL x NORMAL | AA and AA | A/A x A/A | 100% AA | 100% NORMAL | 100% SANO |
| NORMAL x CARRIER | AA y AB | A/A x A/B | 50% AA
50% AB |
50% NORMAL
50% CARRIER |
50% HEALTY
50% AFFECTED |
| NORMAL x AFECTADO | AA and BB | A/A x B/B | 100% AB | 100% PORTADOR | 100% AFECTADO |
| CARRIER x CARRIER | AB y AB | A/B x A/B | 25% AA
50% AB 25% BB |
25% NORMAL
50% CARRIER 25% AFFECTED |
25% HEALTHY
75% AFFECTED |
|
PORTADOR x AFECTADO |
AB y BB | A/B x B/B | 50% AB
50% BB |
50% CARRIER
50% AFFECTED |
100% AFECTADO |
| AFFECTED x AFFECTED | BB y BB | B/B x B/B | 100% BB | 100% AFECTADO | 100% AFECTADO |