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Neuroaxonal dystrophy (NAD) in dogs is an inherited condition that affects the nervous system.
10 días laborables
Especificaciones
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Hisopo, sangre EDTA, sangre Heparina, Semen, Tejido |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Información específica de la prueba
Neuroaxonal dystrophy (NAD) in dogs is an inherited condition that affects the nervous system. In the condition, there is swelling of cells in the brain which affect the communication with nerve cells. NAD can be present at birth or develop later in a dog’s life, leading to neurological dysfunction and loss of coordination.
There are multiple variants of mutations known in different breeds. In the Toy Australian Shepherd and Miniature American Shepherd, a variant of the disorder has been observed which is probably caused by a recessive mutation to the gene RNF170.
Características clínicas
Los perros afectados muestran signos neurológicos lentamente progresivos que pueden incluir ataxia (pérdida de coordinación), debilidad de las extremidades traseras, arrastre de los dedos de los pies al caminar, convulsiones y comportamiento temeroso.
Información adicional
Referencias
Pubmed ID: DOI: 10.21203/rs.3.rs-3914204/v1
Omia ID: