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Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds.
10 días laborables
Especificaciones
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Hisopo, sangre EDTA, sangre Heparina, Semen, Tejido |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Información específica de la prueba
Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds. A dog that retains too much copper from its diet suffers from copper toxicosis, which causes liver damage and associated negative effects.
In the Bedlington Terrier, a recessive mutation to the gene COMMD1 (also known as MURR1) is known to cause elevated copper levels, resulting in copper toxicosis.
While copper toxicosis also occurs in breeds such as the Doberman and Labrador Retriever, the disorder in those breeds is caused by a mutation to another gene, ATP7B.
Características clínicas
Los signos clínicos de daño hepático como resultado de la toxicosis por cobre pueden incluir hígado inflamado, anorexia, vómitos, letargo, pérdida de peso, ictericia e hinchazón del abdomen.
La toxicosis por cobre se puede mitigar con una dieta especializada baja en cobre y alta en zinc.
Información adicional
Con los informes actuales no puede ser indicado que la canceladura en el gene COMMD1 es la única causa del toxicosis de cobre.
Referencias
Pubmed ID: 16293123
Omia ID: 1988